重组人ASGR1蛋白-ACROBiosystems百普赛斯

Human ASGR1 / ASGPR1 Protein, His Tag (MALS & SPR verified)

分子别名（Synonym）

ASGP-R 1, ASGPR 1, C-type lectin domain family 4 member H1, Hepatic lectin H1, HL-1

表达区间及表达系统（Source）

Human ASGR1 Protein, His Tag (AS1-H5243) is expressed from human 293 cells (HEK293). It contains AA Gln 62 - Leu 291 (Accession # P07306-1).

Predicted N-terminus: His

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the N-terminus.

The protein has a calculated MW of 28.3 kDa. The protein migrates as 36-45 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>90% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, 0.5M Arginine, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

ASGPR是一种跨膜C型凝集素，可识别多种含有末端半乳糖（Gal）或N-乙酰半乳糖胺（GalNAc）残基的配体，已被鉴定为肝细胞上的高选择性受体。ASGR由主要亚基（ASGR1）和次要亚基（ASDR2）组成。ASGR1已被证明能有效靶向质膜，并经历组成性内吞和再循环，主要在人类肝脏中表达。