重组人B7-H6蛋白-ACROBiosystems百普赛斯

Human B7-H6 / NCR3LG1 Protein, His Tag

分子别名（Synonym）

B7-H6,NCR3LG1,B7 Homolog 6

表达区间及表达系统（Source）

Human B7-H6 Protein, His Tag (B76-H52H8) is expressed from human 293 cells (HEK293). It contains AA Asp 25 - Ser 262 (Accession # Q68D85-1).

Predicted N-terminus: Asp 25

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 28.6 kDa. The protein migrates as 38-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>90% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

B7基因家族在调节适应性免疫系统中至关重要。其中之一是最近发现的B7H6。人类和大鼠只有一个B7H6基因；然而，在爪蟾基因组中的单个大簇中检测到许多B7H6基因。

嵌合抗原受体（CAR）T细胞疗法在临床试验中已被证明对B细胞白血病具有持久和潜在的疗效。在这项研究中，靶向NK细胞激活受体NKp30的配体B7H6，以创建靶向多种肿瘤类型的CAR。B7H6在各种原发性人类肿瘤上表达，包括白血病、淋巴瘤和胃肠道间质瘤，但在正常组织上不是组成型表达的。