重组人CA125/MUC16蛋白-ACROBiosystems百普赛斯

Human CA125 / MUC16 (13810-14451) Protein, His Tag (MALS verified)

分子别名（Synonym）

CA125,CA-125,CA125MUC-16,FLJ14303,MUC16,mucin 16,mucin-16

表达区间及表达系统（Source）

Human CA125 (13810-14451), His Tag (CA5-H52H6) is expressed from human 293 cells (HEK293). It contains AA Pro 13810 - Pro 14451 (Accession # Q8WXI7-1).

Predicted N-terminus: Pro 13810

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 73.7 kDa. The protein migrates as 90-130 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 0.1 EU per μg by the LAL method.

纯度（Purity）

>95% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

CA125，也被称为MUC16，是一种粘蛋白，可在I型跨膜或分泌形式中发现，用于监测上皮性卵巢癌症治疗的进展。CA 125分子几乎可以肯定是一种以O-键为主的糖蛋白。它在大小和电荷方面都是异质的，很可能是由于侧链在体液中的持续去糖基化。在自然条件下，它以非常大的复合体（可能高达400万道尔顿）的形式存在。