重组人CD79B蛋白-ACROBiosystems百普赛斯

Human CD79B Protein, His Tag (MALS verified)

分子别名（Synonym）

CD79b,B29,IGB,Ig-beta

表达区间及表达系统（Source）

Human CD79B, His Tag (CDB-H52H3) is expressed from human 293 cells (HEK293). It contains AA Ala 29 - Asp 159 (Accession # P40259-1).

Predicted N-terminus: Ala 29

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 17.1 kDa. The protein migrates as 30-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>90% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, 0.2 M Arginine, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

B细胞抗原受体复合物相关蛋白β链（CD79b）也称为B细胞特异性糖蛋白B29、Igβ、免疫球蛋白相关B29蛋白、B29和IGB，它是一种单程I型膜蛋白，含有一个Ig样V型（免疫球蛋白样）结构域和一个ITAM结构域。CD79b需要与CD79A协同作用，以启动由B细胞抗原受体复合物（BCR）激活的信号转导级联。CD79b可能通过招募磷酸化CD79A的激酶或招募与CD79A结合并保护其免受去磷酸化的蛋白质来增强CD79A磷酸化。CD79b的缺陷是6型无丙种球蛋白血症（AGM6）的原因，AGM6是一种原发性免疫缺陷，其特征是由于B细胞发育的早期阻断，血清抗体极低或缺失，循环B细胞低或缺失。