重组人Claudin-18.2蛋白-ACROBiosystems百普赛斯

Human Claudin-18.2 Full Length Protein (VLP)

分子别名（Synonym）

Claudin-18.2,CLDN18,Claudin-18

表达区间及表达系统（Source）

Human Claudin-18.2 Full Length Protein-VLP (CL2-H52P7) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Val 261 (Accession # P56856-2 ).

Predicted N-terminus: Met 1

蛋白结构（Molecular Characterization）

The protein has a calculated MW of 27.7 kDa | 56.1 kDa.

病毒样颗粒（VLP）是由病毒的包膜/衣壳蛋白自组装形成的。膜蛋白可以用HEK293细胞培养物产生的VLP原位构建。这些VLP将构象完整的膜蛋白直接集中在细胞表面，并产生可溶性高浓度蛋白，非常适合免疫和抗体筛选。

The VLPs provide the display of properly folded membrane proteins in their native cellular membrane in a compact size of 100~300 nm diameter (similar to the size of most viruses) making it optimal targets for dendritic cells in vivo and surface attachment for phage display.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

制剂（Formulation）

The VLPs are highly immunogenic, so the immunization strategy should be optimized (antigen dose, regimen and adjuvant).

Supplied as 0.2 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

运输（Shipping）

This product is supplied and shipped with dry ice, please inquire the shipping cost.

存储（Storage）

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

The product MUST be stored at -70°C or lower upon receipt;

-70°C for 12 months under sterile conditions.

背景（Background）

Claudins（CLDN）是一个形成紧密连接并维持上皮细胞和内皮细胞极性的蛋白质家族。CLDN18在胃和肺中特异性表达。在通过选择性剪接产生的两种CLDN18同种型转录物中，CLDN18.2是一种高选择性的胃谱系标记物，可决定肿瘤条件下的胃表型，而CLDN18.1是肺特异性的。CLDN18.2是一种高度选择性的胃谱系抗原，仅在短暂分化的胃上皮细胞上表达，其对抗体药物的可及性有限。14，15 CLDN18.2在恶性转化过程中保持不变，因此经常显示在人类癌症细胞表面。