重组人IL-4Ra蛋白-ACROBiosystems百普赛斯

Human IL-4 R alpha / CD124 Protein, His Tag (MALS verified)

分子别名（Synonym）

IL4R,CD124,IL4RA

表达区间及表达系统（Source）

Human IL-4 R alpha, His Tag (ILR-H5221) is expressed from human 293 cells (HEK293). It contains AA Met 26 - His 232 (Accession # NP_000409.1).

Predicted N-terminus: Met 26

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 24.6 kDa. The protein migrates as 36-50 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>95% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

IL-4是一种多效性细胞因子，由活化的Th2细胞和肥大细胞产生，在免疫反应中发挥关键作用。IL-4的作用是在与存在于造血细胞和非造血细胞上的高亲和力受体复合物结合后介导的。造血细胞对IL-4的反应是由一种高亲和力受体复合物介导的，该复合物由140 kDa的IL4Rα（CD124）亚基和70 kDa常见细胞因子γc链（CD132）组成。

白细胞介素4受体（IL4R）也称为CD124、IL4Rα和BSF受体，是一种由活化的Th2细胞和肥大细胞产生的I型细胞因子受体，在Th2偏向性免疫反应、替代巨噬细胞活化、粘膜免疫、过敏性炎症、肿瘤进展和动脉粥样硬化形成中发挥重要作用。编码的IL4R蛋白的可溶性形式可以通过交替剪接变体或通过膜结合蛋白的蛋白水解产生，并且这种可溶性形式可以抑制IL4介导的细胞增殖和T细胞上调IL5。IL4R可以选择性地与IL13Ra1结合以形成对IL4和IL13都有反应的II型受体。白细胞介素-4受体已被证明与SHC1相互作用。