重组人Cadherin-17/CDH17蛋白-ACROBiosystems百普赛斯

Human Cadherin-17 / CDH17 Protein, His Tag

分子别名（Synonym）

Cadherin-17,CDH17,HPT-1,LI-cadherin

表达区间及表达系统（Source）

Human Cadherin-17, His Tag (CA7-H52H3) is expressed from human 293 cells (HEK293). It contains AA Gln 23 - Met 787 (Accession # Q12864).

Predicted N-terminus: Gln 23

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 86.9 kDa. The protein migrates as 95-120 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>95% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in 20 mM Tris, 150mM NaCl, pH8.0 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

Cadherin-17，也称为肝肠钙粘蛋白，属于钙依赖性细胞粘附分子钙粘蛋白家族。体内研究表明，CDH17敲除通过激活半胱氨酸天冬氨酸蛋白酶-3活性导致凋亡性PC肿瘤死亡。综上所述，CDH17通过调节肿瘤凋亡信号通路作为对PC生长至关重要的致癌分子发挥作用，并且CDH17可以作为开发抗PC治疗方法的靶点。