重组人DR3蛋白-ACROBiosystems百普赛斯

Human DR3 Protein, Fc Tag (MALS verified)

分子别名（Synonym）

TNFRSF25,DR3,APO3,DDR3,TNFRSF12,WSL,WSL1

表达区间及表达系统（Source）

Human DR3 Protein, Fc Tag (DR3-H5253) is expressed from human 293 cells (HEK293). It contains AA Gln 25 - Gln 199 (Accession # Q93038-1).

蛋白结构（Molecular Characterization）

This protein carries a human IgG1 Fc tag at the C-terminus.

The protein has a calculated MW of 45.5 kDa. The protein migrates as 53-63 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>90% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

肿瘤坏死因子受体超家族成员25（TNFRSF25）也称为Apo-3、死亡受体3（DDR3或DR3）、细胞凋亡诱导受体AIR、细胞凋亡介导受体TRAMP、淋巴细胞相关死亡受体Apo-3，是TNF受体超家族的成员。TNFRSF25是一种同源二聚体蛋白，它可以通过死亡结构域与TNFRSF1和TRADD强烈相互作用，激活至少两种不同的信号级联，即凋亡和NF-kappa-B信号。TNFRSF25是TNFSF12/APO3L/TWEAK的受体。