重组人BCMA蛋白-ACROBiosystems百普赛斯

FITC-Labeled Human BCMA / TNFRSF17 Protein, Fc Tag

分子别名（Synonym）

TNFRSF17,CD269,BCM,BCMA

表达区间及表达系统（Source）

FITC-Labeled Human BCMA, Fc Tag (Cat. No. BCA-HF254) is expressed from human HEK293 cells. It contains AA Met 1 - Ala 54 (Accession # Q02223-1). It is the FITC labeled form of Human BCMA, Fc Tag (Cat. No. BC7-H5254).

Predicted N-terminus: Met 1

蛋白结构（Molecular Characterization）

This protein carries a human IgG1 Fc tag at the C-terminus.

The protein has a calculated MW of 32.0 kDa. The protein migrates as 35-44 kDa under reducing (R) condition, and 60-75 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.

偶联（Conjugate）

FITC

Excitation source: 488 nm spectral line, argon-ion laser

Excitation Wavelength: 488 nm

Emission Wavelength: 535 nm

标记（Labeling）

The primary amines in the side chains of lysine residues and the N-terminus of the protein are conjugated with FITC using standard chemical labeling method. The residual FITC is removed by molecular sieve treatment during purification process.

蛋白标记度（Protein Ratio）

The FITC to protein molar ratio is 1.5-3.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>92% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please protect from light and avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

肿瘤坏死因子受体超家族成员17（TNFRSF17）也称为B细胞成熟蛋白（BCMA）、CD抗原CD269，是TNF受体超家族的成员。TNFRSF17含有一个TNFR-Cys重复序列。TNFRSF17在成熟的B细胞中表达，但在T细胞或单核细胞中不表达。TNFRSF17是TNFSF13B/BLyS/BAFF和TNFSF13/APRIL的受体。TNFRSF17-促进B细胞存活并在体液免疫调节中发挥作用。TNFRSF17可激活NF-κB和JNK。