GMP级Anti CD3抗体(OKT3)-ACROBiosystems百普赛斯

GMP Monoclonal Anti-Human CD3 Antibody (OKT3)

Designed under ISO 9001:2015 and ISO 13485:2016;

Manufactured and QC tested under a GMP compliance factory;

FDA DMF filed;

Animal-Free materials;

Beta-lactam materials free;

Batch-to-batch consistency;

Stringent quality control tests.

抗体来源（Source）

HEK293 cells-expressed human GMP Monoclonal Anti-Human CD3 Antibody (OKT3).

亚型（Isotype）

Mouse IgG2a/kappa

特异性（Specificity）

The cross-reactivity with other species has not been tested yet.

纯度（Purity）

>95% as determined by SDS-PAGE.

>95% as determined by SEC-HPLC.

内毒素（Endotoxin）

Less than 2 EU/mg by the LAL method.

蛋白A残留（Protein A）

<5 ppm of protein tested by ELISA.

宿主蛋白残留（Host Cell Protein）

<0.5 ng/μg of protein tested by ELISA.

宿主核酸残留（Host Cell DNA）

<0.02 ng/μg of protein tested by qPCR.

无菌（Sterility）

The sterility testing was performed by membrane filtration method described in CP<1101>, USP<71>and Eur. Ph. 2.6.1.

支原体（Mycoplasma）

Negative.

制剂（Formulation）

Supplied as 0.2 μm filtered solution in PBS, pH7.4 with protectants.

Contact us for customized product form or formulation.

运输（Shipping）

This product is supplied and shipped with dry ice, please inquire the shipping cost.

存储（Storage）

For long term storage, the product should be stored at liquid state at -70°C.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

2-8°C for 12 months under sterile condition;

-70°C for 5 years.

背景（Background）

CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.