Anti IL-15抗体-ACROBiosystems百普赛斯

Anti-Human IL-15 (9B5G1) mAb, Mouse IgG1

抗体来源（Source）

Anti-Human IL-15 (9B5G1) mAb, Mouse IgG1 is a Mouse monoclonal antibody recombinantly expressed from HEK293 cells.

克隆号（Clone）

9B5G1

宿主（Host Species）

Human

亚型（Isotype）

Mouse IgG1 | Mouse Kappa

偶联（Conjugate）

Unconjugated

抗体类型（Antibody Type）

Recombinant Monoclonal

免疫原（Immunogen）

Recombinant Human IL15 is expressed from human HEK293 cells.

特异性（Specificity）

This product is a specific antibody specifically reacts with IL 15, Human. No cross-reactivity is detected with other human cytokines, including IL-2, IL-4, IL-6, IL-10, IL-21,GM-CSF,TNF-alpha and IFNγ.

应用（Application）

纯度（Purity）

>95% as determined by SDS-PAGE.

纯化（Purification）

Protein A purified/ Protein G purified

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS,pH 7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

IL-15抗体用户评价

背景（Background）

Interleukin 15 is also known as IL15, IL-15, and is a cytokine with structural similarity to IL-2. Like IL-2, IL-15 binds to and signals through the IL-2/IL-15 beta chain (CD122) and the common gamma chain (gamma-C, CD132). IL-15 is secreted by mononuclear phagocytes (and some other cells) following infection by virus(es). This cytokine induces cell proliferation of natural killer cells; cells of the innate immune system whose principal role is to kill virally infected cells. Interleukin 15 (IL-15) regulates T and natural killer (NK) cell activation and proliferation. Survival signals that maintain memory T cells in the absence of antigen are provided by IL-15. This cytokine is also implicated in NK cell development. In rodent lymphocytes, IL-15 prevents apoptosis by inducing an apoptosis inhibitor, BCL2L1/BCL-x(L). IL-15 has been shown to enhance the anti-tumor immunity of CD8+ T cells in pre-clinical models. A phase I clinical trial to evaluate the safety, dosing, and anti-tumor efficacy of IL-15 in patients with metastatic melanoma and renal cell carcinoma (kidney cancer) has begun to enroll patients at the National Institutes of Health.