MT2 Melanotan II 美拉诺坦 II MT2 peptide 美黑素

MT2 Melanotan II 美拉诺坦 II MT2 peptide 美黑素

CAS号:

121062-08-6

英文名:

MelanotanII

英文别名:

MT2;Melanotan2;MelanotanIIAcetate(MT-2);MT-Ⅱ;MT-II(MelanotanII);AC-NLE-CYCLO[(BETA-D)-HFRW-(EPSILON-K)]-NH2;MTII;MTIl;Melanotan②;MelanotanЦ

中文名:

美拉诺坦II中文别名:美黑素;美拉诺坦2;美拉诺坦二;美拉诺坦Ⅱ;美那诺坦II;美诺拉坦-2;美拉诺坦杂质;美拉诺坦LL;美拉诺坦II;醋酸美拉诺坦2

CB Number:

CB9213757

分子式:                                                 

C50H69N15O9

美拉诺坦II 用途与生产工艺

用途

美拉诺坦 II 是一种实验室制造的化学物质，与人体内的激素相似。美拉诺坦 II 已被证明对人类具有黑色素生成（鞣制）和壮阳作用。

生物活性

Melanotan (MT)-II是一种合成的黑皮质素 (melanocortin) 受体激动剂。它是可注射用的多肽荷尔蒙，可促进晒黑。

体外研究

Melanotan (MT)-II is a potent non-selective melanocortin receptor agonist with high affinity for MC1, MC3, MC4, and MC5 receptor subtypes which are involved in the regulation of a number of physiological systems such as the pigmentary system, energy homoeostasis, sexual functioning, the immune system, inflammation, and the cardiovascular system.

体内研究

Melanotan (MT)-II exerts a dose-dependent inducer activity on erection by eliciting erectile events and shortening of the first erectile event to occur. Erectile responses elicited by cavernous nerve stimulation are increased after i.v. melanotan (MT)-II (1 mg/kg), thereby exerting facilitator effect on erection. Melanotan (MT)-II promotes peripheral nerve regeneration and has neuroprotective properties in the rat. Melanotan (MT)-II significantly enhances the recovery of sensory function following a crush lesion of the sciatic nerve in the rat at a dose of 20 μg/kg per 48 h, s.c., but not at a dose of 2 or 50 μg/kg. Melanotan (MT)-II is a potent initiator of penile erection in men with erectile dysfunction. Melanotan (MT)-II reduces food intake and body weight and invokes thermogenic responses in a mouse model.

参考质量标准

外观: 白色粉末

纯度(HPLC)≥98.0%

醋酸根含量≤12.0%

水分含量≤8.0%

肽含量≥80.0%

内毒素≤50EU/mg

氨基酸组成分析≤±10%