IL-1R1蛋白-ACROBiosystems百普赛斯

IL-1R1产品信息

别称：IL-1R1

物种：Human

属性：Protein

标记：Unconjugated

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>95% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

IL-1R1分子背景

IL1R1也称为白细胞介素-1受体1型，是IL1A、IL1B和IL1RN的受体。与白细胞介蛋白-1结合后，与辅助受体IL1RAP结合形成高亲和力白细胞介素-1受体复合物，介导白细胞介导NF-kappa-B、MAPK和其他途径的白细胞介介素-1依赖性激活。信号传导涉及通过受体/共受体亚基的相应TIR结构域招募衔接分子，如TOLLIP、MYD88和IRAK1或IRAK2。以相当的亲和力结合配体，与拮抗剂IL1RN结合可防止与IL1RAP结合形成信号复合物。参与IL1B介导的T辅助1（Th1）细胞产生IFNG的共刺激。