颗粒蛋白前体Progranulin（GRN）蛋白-ACROBiosystems百普赛斯

Progranulin产品信息

英文名称：Progranulin

中文名称：颗粒蛋白前体

靶点别称：GRN

物种：Human

属性：Protein

标记：Unconjugated

内毒素（Endotoxin）

Less than 0.01 EU per μg by the LAL method.

纯度（Purity）

>95% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

Progranulin分子背景

Progranulin是一种分泌型糖蛋白，在人类中由单个GRN基因编码。Progranulin由12-半胱氨酸granulin基序的七个半串联重复的不相同拷贝组成。许多细胞过程和疾病都与这种独特的多效性因子有关，包括但不限于胚胎发生、肿瘤发生、炎症、伤口修复、神经变性和溶酶体功能。由GRN基因内的常染色体显性突变引起的半相合性导致额颞叶变性，这是一种进行性神经元萎缩，在患者中表现为额颞叶痴呆。