补体因子D（Complement factor D）-ACROBiosystems百普赛斯

Complement Factor D产品信息

英文名称：Complement factor D

中文名称：补体因子D

靶点别称：CFD,Adipsin,PFD

物种：Human/Rhesus macaque/Cynomolgus

属性：Protein

标记：Unconjugated

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>95% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH8.0. Normally glycerol is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

Complement Factor D分子背景

补体因子D（CFD）也被称为Adipsin、C3转化酶激活剂、Propertin因子D（PFD），它含有一个肽酶S1结构域，属于肽酶S1家族。当因子B与因子C3b复合时，CFD/Adipsin会裂解因子B，激活C3bbb复合物，使其成为替代途径的C3转化酶。CFD/Adipsin是一种丝氨酸蛋白酶，可刺激脂肪细胞中甘油三酯积累的葡萄糖转运，并抑制脂肪分解。CFD/Adipsin的缺陷是补体因子D缺乏症的原因，后者易患侵袭性脑膜炎球菌病。