ADORA2A蛋白-ACROBiosystems百普赛斯

ADORA2A产品信息

英文名称：Adenosine A2a receptor

中文名称：腺苷A2a受体

靶点别称：ADORA2A

物种：Human

属性：Protein

标记：Unconjugated

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>90% as determined by SDS-PAGE.

制剂（Formulation）

This product is not suitable for cell based experiments due to cytotoxicity of DDM.

DDM and CHS are INDISPENSABLE to keep membrane protein soluble and active, under no circumastance should you remove DDM and CHS.

DDM/CHS buffer (DC-11) is sold separately and not included in protein, and please contact us if you need the buffer.

If glycerol is not compatible to your application, remove glycerol just before immediate experiment, and NEVER store glycerol-free protein solution.

Supplied as 0.2 μm filtered solution in 50 mM HEPES, 150 mM NaCl, DDM, CHS, pH7.5 with glycerol as protectant.

Contact us for customized product form or formulation.

运输（Shipping）

This product is supplied and shipped with dry ice, please inquire the shipping cost.

存储（Storage）

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

The product MUST be stored at -70°C or lower upon receipt;

-70°C for 3 months under sterile conditions.

ADORA2A分子背景

该基因编码鸟嘌呤核苷酸结合蛋白（G蛋白）偶联受体（GPCR）超家族的成员，该超家族又分为类别和亚型。受体是七通道跨膜蛋白，对细胞外信号作出反应并激活细胞内信号转导通路。这种蛋白是A2A亚型的腺苷受体，它使用腺苷作为首选的内源性激动剂，并优先与G（s）和G（olf）家族的G蛋白相互作用，以增加细胞内cAMP水平。它在许多生物功能中起着重要作用，如心律和循环、脑和肾血流、免疫功能、疼痛调节和睡眠。它与炎症性疾病和神经退行性疾病等病理生理条件有关。选择性剪接导致多种转录变体。已经鉴定出一种由上游SPECC1L（具有calponin同源性和卷曲螺旋结构域1-like的精子抗原）和ADORA2A（腺苷A2a受体）基因序列组成的通读转录本，但人们认为它是非编码的。