酪氨酸蛋白激酶JAK1-ACROBiosystems百普赛斯

JAK1产品信息

英文名称：Tyrosine-protein kinase JAK1

中文名称：酪氨酸蛋白激酶JAK1

靶点别称：JAK1

物种：Human

属性：Protein

标记：Unconjugated

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>95% as determined by SDS-PAGE.

制剂（Formulation）

Delivered as bulk protein in a 0.2 μm filtered solution of 50 mM Tris, 500 mM NaCl, 2 mM TCEP, pH8.0 with glycerol as protectant.

Contact us for customized product form or formulation.

运输（Shipping）

This product is supplied as sterile liquid solution and shipped frozen with dry ice.

存储（Storage）

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

The product MUST be stored at -70°C or lower upon receipt;

-70°C for 3 months under sterile conditions.

JAK1分子背景

JAK1 is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. It interacts with the common gamma chain (γc) of type I cytokine receptors, to elicit signals from the IL-2 receptor family (e.g. IL-2R, IL-7R, IL-9R and IL-15R), the IL-4 receptor family (e.g. IL-4R and IL-13R), the gp130 receptor family (e.g. IL-6R, IL-11R, LIF-R, OSM-R, cardiotrophin-1 receptor (CT-1R), ciliary neurotrophic factor receptor (CNTF-R), neurotrophin-1 receptor (NNT-1R) and Leptin-R). Jak1 plays a critical role in initiating responses to multiple major cytokine receptor families. Expression of JAK1 in cancer cells enables individual cells to contract, potentially allowing them to escape their tumor and metastasize to other parts of the body.