IGFBP3蛋白-ACROBiosystems百普赛斯

IGFBP3产品信息

英文名称：Insulin-like growth factor binding protein III

中文名称：胰岛素样生长因子结合蛋白-III

靶点别称：IGFBP3,BP-53,IBP3

物种：Human

属性：Protein

标记：Unconjugated

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>90% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

IGFBP3分子背景

胰岛素样生长因子结合蛋白3也称为IGFBP3，是一种在人类中由IGFBP3基因编码的蛋白质。IGFBP3与IGF1或IGF2以及糖蛋白胰岛素样生长因子酸不稳定亚基（ALS）形成约140~150 kDa的三元复合物，从而改变IGFs与其细胞表面受体的相互作用。IGFBP3根据细胞环境发挥促凋亡或生长刺激作用。研究表明，IGFBP3可以诱导依赖或独立于IGF-IGF受体轴的凋亡，因此在某些癌症中充当肿瘤发生和进展的负调节因子。在肝脏的非分支细胞中发现了最高的表达水平。表达水平在子宫外生活期间也较高，在青春期达到峰值。