GM-CSF R alpha蛋白-ACROBiosystems百普赛斯

GM-CSF R alpha产品信息

英文名称：Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

中文名称：粒细胞-巨噬细胞集落刺激因子受体α亚基

靶点别称：GM-CSF R alpha,GM-CSF-R-alpha,GMCSFR-alpha,GMR-alpha,CSF2RA,CSF2R,CSF2RY,CDw116,CD116

物种：Human/Mouse

属性：Protein

标记：Unconjugated

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>95% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

GM-CSF R alpha分子背景

GM-CSF Rα（粒细胞-巨噬细胞集落刺激因子受体亚基α）也称为CSF2RA、CD116、GMRα。粒细胞-巨噬细胞集落刺激因子低亲和力受体。传递导致造血细胞增殖、分化和功能激活的信号。遗传性肺泡蛋白沉积症（hPAP）是一种罕见的肺表面活性物质积聚和低氧性呼吸衰竭疾病，由CSF2RA（编码粒细胞/巨噬细胞集落刺激因子[GM-CSF]受体α链[CD116]）突变引起，导致肺泡巨噬细胞对GM-CSF依赖性肺表面活性物质的清除减少。