FGF23蛋白-ACROBiosystems百普赛斯

FGF-23产品信息

英文名称：Fibroblast growth factor 23

中文名称：成纤维细胞生长因子-23

靶点别称：FGF23,HYPF,FGF-23,ADHR,HPDR2

物种：Human

属性：Protein

标记：Unconjugated

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>95% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in 20 mM MOPS, 150 mM NaCl, 5 mM EDTA, 2 mM DTT, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

FGF-23分子背景

成纤维细胞生长因子23（FGF23）是FGF家族的内分泌成员，主要在骨骼中产生，分泌后与FGF受体和辅助受体αKlotho形成复合物。FGF23可以发挥多种内分泌功能，如作为肾脏的激素，刺激磷酸盐排泄和抑制活性维生素D 1,25（OH）2D3的形成。此外，它对几种细胞类型具有旁分泌活性，包括中性粒细胞和肝细胞。FGF23和磷酸盐是癌症的相关因素。FGF23对于那些主要影响骨骼（例如多发性骨髓瘤）或以骨骼转移为特征的癌症形式特别重要。