Jagged 1/CD339蛋白-ACROBiosystems百普赛斯

Jagged 1产品信息

英文名称：Protein jagged-1

中文名称：Jagged-1蛋白

靶点别称：CD339,JAG1,Jagged1,hJ1,JAGL1

物种：Human

属性：Protein

标记：Unconjugated

内毒素（Endotoxin）

Less than 0.1 EU per μg by the LAL method.

无菌（Sterility）

The sterility testing was performed by membrane filtration method.

支原体（Mycoplasma）

Negative.

纯度（Purity）

>90% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

Jagged 1分子背景

蛋白jagged-1（JAG1）也称为Jagged1、hJ1、JAGL1和CD339，它是一种单程I型膜蛋白，含有一个DSL结构域和15个EGF样结构域。JAG1在成人和胎儿组织中广泛表达，JAG1在宫颈鳞状细胞癌中的表达上调，在骨髓细胞系HS-27a中也有表达。JAG1是多种Notch受体的配体，参与Notch信号传导的介导。JAG1参与哺乳动物心血管发育的早期和晚期。JAG1通过相似性抑制成肌细胞分化，并增强成纤维细胞生长因子诱导的血管生成（体外）。