NPC2/HE1蛋白-ACROBiosystems百普赛斯

NPC2产品信息

别称：NPC2,HE1

物种：Human

属性：Protein

标记：Unconjugated

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>95% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

NPC2分子背景

尼曼-匹克病C2型蛋白（NPC2）也称为附睾分泌蛋白E1和人附睾特异性蛋白1（HE1）。NPC2是一种细胞内胆固醇转运蛋白，与NPC1协同作用，在胆固醇从内体/溶酶体室排出中起着重要作用。NPC1和NPC2都起着细胞“标签团队二元体”（TTD）的作用，催化胆固醇在晚期内体（LE）的多囊环境中的动员，以通过LE的限制性双层实现排出。此外，NPC2结合晚期内体/溶酶体内腔中LDL释放的未酯化胆固醇，并将其转移到NPC1 N末端结构域的胆固醇结合袋中。此外，NCP2的分泌形式通过刺激ABCG5/ABCG8介导的胆固醇转运来调节胆汁胆固醇分泌。