CLEC5A蛋白-ACROBiosystems百普赛斯

CLEC5A产品信息

别称：CLEC5A,MDL1

物种：Human

属性：Protein

标记：Unconjugated

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>95% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

CLEC5A分子背景

CLEC5A，也称为MDL1和MDL-1，是C型凝集素/C型凝集素样结构域（CTL/CTLD）超家族的成员。CLEC5A在单核细胞、巨噬细胞和中性粒细胞上表达。在类风湿性关节炎中，其在单核细胞上的表达上调。CLEC5A与dnax活化蛋白12结合，可能在细胞活化中发挥作用。它还具有破骨细胞生成的积极调节作用。CLEC5A是自身免疫性关节炎症期间滑膜损伤和骨侵蚀的关键调节因子。登革热病毒与CLEC5A的结合通过TYROBP的磷酸化触发信号传导，这种相互作用不会导致病毒进入，但会刺激促炎细胞因子的释放。