CRTAM蛋白-ACROBiosystems百普赛斯

CRTAM产品信息

别称：CRTAM,CD355

物种：Human/Cynomolgus

属性：Protein

标记：Unconjugated

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>90% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

CRTAM分子背景

I类限制性T细胞相关分子（CRTAM）是连接蛋白家族和免疫球蛋白超家族的成员，也被称为细胞毒性和调节性T细胞分子，由活化的CD8+和NK T细胞表达。CRTAM存在于脾脏、胸腺、小肠、外周血中，令人惊讶的是，在大脑中，它被小脑的浦肯野细胞高度表达。CRTAM/IGSF4粘附的高亲和力使CRTAM能够破坏IGSF4的同型相互作用（3-5）。表达CRTAM的CD8+细胞与IGSF4和T细胞受体的共结合诱导IFN-γ或IL-22的产生增加（3，4）。此外，还提出了通过NK细胞介导的对表达IGSF4的肿瘤的排斥在癌症监测中的作用。