凝血因子XI,FXI蛋白-ACROBiosystems百普赛斯

Coagulation factor XI产品信息

英文名称：Coagulation factor XI

中文名称：凝血因子XI

靶点别称：FXI,PTA,F11

物种：Human/Rhesus macaque

属性：Protein

标记：Biotin-labeled/Unconjugated

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>90% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in 20 mM HEPES,150 mM NaCl,pH7.5 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

Coagulation factor XI分子背景

凝血因子XI以酶原的形式存在于血浆中，酶原是一种独特的血浆凝固酶，因为它是由两条由二硫键连接的相同多肽链组成的同二聚体。在血浆因子XI的激活过程中，两个链中的每个链中的因子XIIa（或XII）切割内部肽键，产生激活的因子XIa，一种丝氨酸蛋白酶，由两个重链和两个轻链通过二硫键连接在一起。这种激活的血浆因子XI通过激活因子IX触发凝血内在途径的中期。该因子的缺陷导致Rosenthal综合征，一种凝血异常。