APP重组蛋白-ACROBiosystems百普赛斯

APP产品信息

英文名称：Beta amyloid A4 protein

中文名称：β-淀粉状蛋白A4

靶点别称：ABPP,APP,Amyloid-beta A4 protein

物种：Human/Mouse

属性：Protein/Cell

标记：Unconjugated

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>95% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

APP用户评价

APP分子背景

淀粉样前体蛋白（APP）是一种I型完整膜蛋白，在许多组织中普遍表达，集中在神经元的突触中。在非淀粉样蛋白生成途径中，大部分APP在质膜上被α-分泌酶切割。淀粉样蛋白生成途径始于BACE1在Aβ结构域N端部分切割β-分泌酶，从名为βCTF或C102的膜锚定片段释放sAPPβ，随后被γ-分泌酶切割以释放Aβ。