aladdin 阿拉丁 S414183 SSE15206 1370046-40-4 99%

中文名：SSE15206

英文名：SSE15206

纯度：≥99%

货号：S414183

Cas号：1370046-40-4

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

SSE15206 SSE15206 is a tubulin polymerization inhibitor that has potent antiproliferative activities in cancer cell lines of different origins and overcomes resistance to microtubule-targeting agents.

Targets

tubulin polymerization

In vitro

Treatment of cells with SSE15206 causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation, a phenotype often associated with drugs that interfere with microtubule dynamics. SSE15206 inhibits microtubule polymerization both in biochemical and cellular assays by binding to colchicine site in tubulin. Prolonged treatment of cells with SSE15206 results in apoptotic cell death accompanied by p53 induction.

Cell Research(from reference)

Cell lines：HCT116 cells 

Concentrations：0.5\u2009μM, 1\u2009μM and 2\u2009μM 

Incubation Time：4, 8, 12, 24 and 36\u2009hours 

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