aladdin 阿拉丁 I413740 IPI-3063 1425043-73-7 98%

中文名：IPI-3063

英文名：IPI-3063

纯度：≥98%

货号：I413740

Cas号：1425043-73-7

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

IPI-3063 is a potent and selectivep110δinhibitor with biochemical IC50 of 2.5 ± 1.2 nM and IC50 values for the other class I PI3K isoforms (p110α, p110β, p110γ) are at least 400-fold higher.

Targets

p110δ (Cell-free assay) 2.5 nM

In vitro

IPI-3063 is a p110δ selective compound with an IC50\u2009=\u20090.1\u2009nM in p110δ-specific cell-based assays and cellular IC50 values for the other class I PI3K isoforms are at least 1,000-fold higher. IPI-3063 potently reduces mouse B cell proliferation, survival, and plasmablast differentiation.

In vivo

IPI-3063 has good pharmacokinetics in mice.

Cell Research(from reference)

Cell lines：purified mouse B cells 

Concentrations：0.01, 0.1, 1, 10, 30, 100\u2009nM 

Incubation Time：48 h 

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