aladdin 阿拉丁 E413293 鞣花酸水合物 314041-08-2 98%

中文名：鞣花酸水合物

英文名：Ellagic Acid hydrate

纯度：≥98%

货号：E413293

Cas号：314041-08-2

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

Ellagic Acid hydrate Ellagic acid is a potent inhibitor of protein kinase CK2 with IC50s of 0.04, 2.9 and 3.5 μM for CK2, Lyn and PKA respectively. It shows potent antioxidant, anti-mutagenic and antidepressant properties.

Targets

CK2 (Cell-free assay); Lyn (Cell-free assay); PKA (Cell-free assay) 0.04 μM; 2.9 μM; 3.5 μM

In vitro

Ellagic acid (EA) is able to inhibit the growth of several cancer cells. EA inhibited cell proliferation in a dose- and time-dependent manner by arresting both cell lines at the G1 phase of the cell cycle, which were from elevating p53 and Cip1/p21 and decreasing cyclin D1 and E levels. EA also induced caspase-3-mediated apoptosis by increasing the Bax\u2009:\u2009Bcl-2 ratio and restored anoikis in ES-2 and PA-1 cells. It is well known to have a free radical scavenging activity. EA reversed epithelial to mesenchymal transition by up-regulating E-cadherin and down-regulating Vimentin.

In vivo

A 90-day subchronic toxicity study further demonstrated that orally feeding EA (9.4, 19.1, 39.1\u2009g/kg b.w., resp.) could not induce mortality or treatment-related clinical signs throughout the experimental period on F344 rats, indicating the low toxicity of EA to mammalians. Furthermore, EA exhibits potent anticancer and anticarcinogenesis activities towards breast, colorectal, oral, prostate, pancreatic, bladder, neuroblastoma, melanoma, and lymphoma cells. Treatment of PANC-1 xenografted mice with EA resulted in significant inhibition in tumor growth and prolong mice survival rate.

Cell Research(from reference)

Cell lines：Ovarian carcinoma ES-2 and PA-1 cells 

Concentrations：10~100\u2009μM 

Incubation Time：12, 24, 48 h 

查看阿拉丁官网此产品相关对应页面：https://www.aladdin-e.com/zh_cn/E413293.html