aladdin 阿拉丁 D414171 DT-061 (SMAP) 1809427-19-7 99%

中文名：DT-061 (SMAP)

英文名：DT-061 (SMAP)

纯度：≥99%

货号：D414171

Cas号：1809427-19-7

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

DT-061 (SMAP) DT-061 (SMAP) is a bioavailable PP2A activator. It decreases cell viability in HCC827 and HCC3255 cell lines, with IC50 values of 14.3 μM and 12.4 μM respectively.

Targets

PP2A

In vivo

PP2A reactivation using single agent SMAP DT-061 is a well-tolerated and orally bioavailable therapeutic strategy that is as efficacious as a combination of kinase inhibitors in antagonizing EGFR-driven TKI-resistant LUAD models. Furthermore, treatment with SMAP can overcome resistance in those models, with an even greater effect when combined with afatinib.

Cell Research(from reference)

Cell lines：HCC827 and H3255 cell lines 

Concentrations：2.5, 5, 7.5, 10, 12.5, 15, 17.5, or 20 μM 

Incubation Time：48 h 

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