aladdin 阿拉丁 B414497 BC1618 2222094-18-8 99%

中文名：BC1618

英文名：BC1618

纯度：≥99%

货号：B414497

Cas号：2222094-18-8

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

BC1618 BC1618 is an orally active Fbxo48 inhibitor that stimulates adenosine monophosphate (AMP)-activated protein kinase (Ampk)-dependent signaling. BC1618 promotes mitochondrial fission, facilitates autophagy and improves hepatic insulin sensitivity.

Targets

Fbxo48

In vitro

BC1618 interrupts Fbxo48/pAmpkα interaction. BC1618 facilitates mitochondrial fission and autophagy.

In vivo

Consistent with augmenting Ampk activity, BC1618 promotes mitochondrial fission, facilitates autophagy and improves hepatic insulin sensitivity in high-fat-diet-induced obese mice.

Cell Research(from reference)

Cell lines：293T cells 

Concentrations：3 μM 

Incubation Time：30\u2009min 

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