aladdin 阿拉丁 G414458 GSK620 2088410-46-0 98%

中文名：GSK620

英文名：GSK620

纯度：≥98%

货号：G414458

Cas号：2088410-46-0

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

GSK620 GSK620 is a pan- BD2 inhibitor, which shows an anti-inflammatory phenotype in human whole blood with excellent broad selectivity, developability, and in vivo oral pharmacokinetics.

Targets

BD2

In vitro

GSK620 is highly selective for the BET-BD2 family of proteins, with >200-fold selectivity over all other bromodomains. GSK620 is capable of reducing the MCP-1 response in a concentration-dependent manner, providing strong evidence that GSK620 is indeed engaging BD2 in cells.

In vivo

GSK620 is a potent and selective pan-BD2 inhibitor with excellent in vivo PK properties and excellent developability properties, with the exception of moderate FaSSIF solubility driven by its highly crystalline nature.

Cell Research(from reference)

Cell lines：human whole blood, hepatocytes 

Concentrations：0.5 μM 

Incubation Time：60 min, 120 min 

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