aladdin 阿拉丁 R414312 RBN-2397 2381037-82-5 99%

中文名：RBN-2397

英文名：RBN-2397

纯度：≥99%

货号：R414312

Cas号：2381037-82-5

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

RBN-2397 RBN-2397 is a potent, selective and orally active NAD+ competitive inhibitor PARP7 with IC50 of <3 nM and Kd of <0.001 μM. RBN-2397 has the potential for the research of tumor treatment.

Targets

PARP7 (Cell-free assay); PARP7 (Cell-free assay) <0.001 μM(Kd); <3 nM

In vitro

RBN-2397 restores cytosolic nucleic acid sensing and blocks cell proliferation in a human lung cancer cell line.

In vivo

RBN-2397 causes complete regressions in human NSCLC NCI-H1373 xenografts and dose-dependent pharmacodynamic effects. RBN-2397 induces tumor-specific adaptive immune memory in CT26 syngeneic model with durable complete responses.

Cell Research(from reference)

Cell lines：NCI-H1373 human lung cancer cells 

Concentrations：0.4 nM to 1000 nM 

Incubation Time：24 h 

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