aladdin 阿拉丁 T414291 TED-347 2378626-29-8 98%

中文名：TED-347

英文名：TED-347

纯度：≥98%

货号：T414291

Cas号：2378626-29-8

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

TED-347 TED-347 is a potent, irreversible, covalent and allosteric inhibitor of the TEAD⋅Yap protein-protein interaction . TED-347 inhibits TEAD4⋅Yap1 protein-protein interaction with an apparent EC50 of 5.9 μM.

Targets

TEAD4⋅Yap1 (Cell-free assay) 5.9 μM(EC50)

In vitro

TED-347 is found to inhibit the protein-protein interaction in a time-dependent manner. TED-347 is shown to functionally disrupt the TEAD·Yap1 interaction in cells and to reduce the viability of patient-derived glioblastoma cell lines.

Cell Research(from reference)

Cell lines：HEK-293 cells, GBM43 cells 

Concentrations：0.5 µM, 1.0 µM, 5.0 µM, 10 µM, 25 µM 

Incubation Time：48 h 

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