aladdin 阿拉丁 T414009 T-3775440 HCl 1422535-52-1 99%

中文名：T-3775440 HCl

英文名：T-3775440 HCl

纯度：≥99%

货号：T414009

Cas号：1422535-52-1

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

T-3775440 HCl T-3775440 HCl is an irreversible LSD1 inhibitor that is highly selective for LSD1 relative to other monoamine oxidases (e.g., MAO-A and MAO-B), with an IC50 value of 2.1 nmol/L.

Targets

LSD1 2.1 nM

In vitro

T-3775440 treatment enforces transdifferentiation of erythroid/megakaryocytic lineages into granulomonocytic-like lineage cells. T-3775440 disrupts the interaction between LSD1 and growth factor-independent 1B (GFI1B), a transcription factor critical for the differentiation processes of erythroid and megakaryocytic lineage cells. 48-hour T-3775440 treatment induces cell-cycle arrest and apoptosis in AEL (TF-1a, HEL92.1.7) and AMKL cell lines (CMK11-5, M07e). T-3775440 treatment increases the G1 and sub-G1 phase populations in TF-1a and CMK11-5 cells.

In vivo

T-3775440 exerts tumor growth suppression in in vivo mouse xenograft models of AML. In mice, T-3775440 treatment results in a transient reduction in platelets, followed by a significant rebound. There is no obvious effect on red blood cell counts following a single administration. T-3775440 also exhibits potent antitumor effects in an additional AEL model of HEL 92.1.7 and an AMKL model of CMK11-5, possessing profound anti-AEL and anti-AMKL activity.

Cell Research(from reference)

Cell lines：TF-1a and CMK11-5 cells 

Concentrations：0, 10, 50 nM (TF-1a cells); 0, 20, 100 nM (CMK11-5 cells) 

Incubation Time：24 and 48 h 

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