aladdin 阿拉丁 B413814 BG45 926259-99-6 97%

中文名：BG45

英文名：BG45

英文别名：BG45|926259-99-6|N-(2-aminophenyl)pyrazine-2-carboxamide|BG-45|N-(2-Aminophenyl)-2-pyrazinecarboxamide|12P6IK4ZUX|UNII-12P6IK4ZUX|2-Pyrazinecarboxamide, N-(2-aminophenyl)-|CHEMBL4283263|BG45, HDAC3 Inhibitor|SCHEMBL18064956|CHEBI:125522|LMWPVSNHKACEKW-UHF

纯度：97%

货号：B413814

包装：10mg、200mg、50mg

Cas号：926259-99-6

存储温度：-20°C储存

产品介绍：

Information

BG45 is a class IHDACinhibitor withIC50of 289 nM, 2.0 µM, 2.2 µM and >20 µM for HDAC3, HDAC1, HDAC2, and HDAC6 in cell-free assays, respectively.

Targets

HDAC3 ; HDAC1 ; HDAC2 289 nM; 2 μM; 2.2 μM

In vitro

BG45 causes significant cell growth inhibition and induces caspase-dependent apoptosis in a series of MM cells. In RPMI8226 cells, BG45 synergistically enhances bortezomib-induced cytotoxicity.

In vivo

In mice bearing MM.1S xenograft of human MM, BG45 (50 mg/kg, i.p.) significantly inhibits MM tumor growth. When in combination with bortezomib, BG45 (50 mg/kg, i.p.) enhances bortezomib-induced cytotoxicity.

Cell Research(from reference)

Cell lines：MM.1S, RPMI8226, U266, H929, MM.1\u2009R, RPMI-LR5, OPM1, OPM2 and RPMI-DOX40 cells 

Concentrations：~30 μM 

Incubation Time：48 h 

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