aladdin 阿拉丁 M414502 MS140 2229974-83-6 96%

中文名：MS140

英文名：MS140

纯度：≥96%

货号：M414502

Cas号：2229974-83-6

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

MS140 MS140 is a specific and highly potent CDK4/6 kinase inhibitor and also a CDK4/6 degrader (PROTAC).

Targets

CDK4 ; CDK6

In vitro

MS140 potently and selectively both inhibits and degrades CDK4/6 kinases in CDK4/6i-S tumor cells by targeting them to the CRL4–CRBN–E3 ubiquitin complex.

In vivo

Treatment of mice with MS140 promoted degradation of CDK4/6 kinases and suppression of RB–E2F output in JeKo-1 (MCL) and Colo25 (colorectal carcinoma) xenografts in vivo.

Cell Research(from reference)

Cell lines：Colo205 cells 

Concentrations：0.3\u2009μM 

Incubation Time：5\u2009h 

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