aladdin 阿拉丁 T413234 四氢小檗碱 522-97-4 99%

中文名：四氢小檗碱

英文名：Tetrahydroberberine

纯度：≥99%

货号：T413234

Cas号：522-97-4

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

Tetrahydroberberine (Canadine) is an isoquinoline alkaloid with micromolar affinity fordopamine D2(antagonist, pKi = 6.08) and5-HT1A(agonist, pKi = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors.

Targets

D2 receptor ; 5-HT1A 6.08(pKi); 5.38(pKi)

In vivo

Oral administration of THB not only resulted in significantly accelerated gastric emptying of normal rats in a bell-shaped relationship, with a maximal efficacy at a dose of 30 μg/kg, but also restored the delayed gastric emptying caused by apomorphine, which might be mediated by an antidopaminergic effect.

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