MARCO重组蛋白-ACROBiosystems百普赛斯

MARCO产品信息

别称：MARCO, SCARA2

物种：Human

属性：Protein

标记：Biotin-labeled/Unconjugated

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>90% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

MARCO分子背景

MARCO也被称为清道夫受体A类成员2和SCARA2。结合革兰氏阳性和革兰氏阴性细菌的模式识别受体（PRR）。也在肺泡巨噬细胞结合未经声波处理的颗粒中发挥作用。与分泌球蛋白SCGB3A2结合。MARCO连接促进巨噬细胞产生炎症介质。MARCO介导的一些配体的内化阻止了它们对细胞表面TLR4的激活，但使它们能够激活细胞内TLR3。MARCO有助于清除凋亡细胞和吸入细菌、肥大细胞介导的矽肺，以及改善过敏原或臭氧诱导的肺部炎症。它是脾边缘区组织和脾巨噬细胞与B细胞相互作用所必需的。