aladdin 阿拉丁 A414443 Acelarin (NUC-1031) 840506-29-8 99%

中文名：Acelarin (NUC-1031)

英文名：Acelarin (NUC-1031)

纯度：≥99%

货号：A414443

Cas号：840506-29-8

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

Acelarin (NUC-1031) Acelarin (NUC-1031, Fosgemcitabine palabenamide, CPF-31, MTL-007, GTPL7389), a prodrug based on an aryloxy phosphoramidate derivative of gemcitabine, is a DNA synthesis inhibitor with EC50 of 0.2 nM.

Targets

DNA synthesis (Cell-free assay) 0.2 nM(EC50)

In vitro

NUC-1031 is a gemcitabine phosphoramidate prodrug with potent cytostatic activity in a range of different tumor cell lines. Importantly, compared with gemcitabine, NUC-1031 activation is significantly less dependent on deoxycytidine kinase and on nucleoside transporters, and it is resistant to cytidine deaminase-mediated degradation.

In vivo

NUC-1031 shows a significant reduction in tumor volumes in vivo in pancreatic cancer xenografts.

Cell Research(from reference)

Cell lines：Murine leukemia L1210, human lymphocyte CEM 

Concentrations：1 μM 

Incubation Time：1 h 

查看阿拉丁官网此产品相关对应页面：https://www.aladdin-e.com/zh_cn/A414443.html