整合素Integrin αMβ2-ACROBiosystems百普赛斯

Integrin αMβ2产品信息

英文名称：Integrin alpha-M/beta-2

中文名称：整合素α-M/β-2复合体

靶点别称：Macrophage-1 Antigen

物种：Human/Canine

属性：Protein

标记：Unconjugated

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>95% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in 50mM Tris 150mM NaCl PH7.5 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

Integrin αMβ2分子背景

整合素ITGAM/ITGB2参与单核细胞、巨噬细胞和粒细胞的各种粘附相互作用，以及介导补体包被颗粒和病原体的摄取。它与CR-3相同，CR-3是第三种补体成分iC3b片段的受体。它可能识别C3b中的R-G-D肽。整合素ITGAM/ITGB2也是纤维蛋白原、因子X和ICAM1的受体。它识别纤维蛋白原γ链的P1和P2肽。与CD177-PRTN3介导的TNF诱导的中性粒细胞活化所需的β亚基ITGB2/CD18相关。可能调节吞噬作用诱导的外渗中性粒细胞凋亡。可能在肥大细胞发育中发挥作用。小胶质细胞中TYROBP/DAP12需要控制小胶质细胞超氧阴离子的产生，超氧阴离子促进大脑发育过程中发生的神经元凋亡。