Activin RIIA产品信息
英文名称:Activin receptor type-2A
中文名称:激活素受体2A
靶点别称:Activin receptor type IIA,ACTRIIA
物种:Human
属性:Protein
标记:Unconjugated
表达区间及表达系统(Source)
Human ACVR2A, Fc Tag (ACA-H5269) is expressed from human 293 cells (HEK293). It contains AA Ala 20 - Pro 135 (Accession # P27037-1).
Predicted N-terminus: Pro
蛋白结构(Molecular Characterization)
![1.jpg 1.jpg](/SupplyImg/2024-04-17/6384897172651340033966546.jpg)
This protein carries a human IgG1 Fc tag at the N-terminus.
The protein has a calculated MW of 39.9 kDa. The protein migrates as 50-60 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
内毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
纯度(Purity)
>90% as determined by SDS-PAGE.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in 51 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
![2.jpg 2.jpg](/SupplyImg/2024-04-17/6384897173686824423673596.jpg)
Activin RIIA用户评价
![3.jpg 3.jpg](/SupplyImg/2024-04-17/6384897174957909131221737.jpg)
Activin RIIA分子背景
Activin receptor type-2A (ACVR2A) is also known as Activin receptor type IIA, ACTR-IIA, ACTRIIA and ACVR2,which is single-pass type I membrane protein. ACVR2A belongs to the protein kinase superfamily,TKL Ser/Thr protein kinase family and TGFB receptor subfamily.On ligand binding,ACVR2A can forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.ACVR2A is Receptor for activin A, activin B and inhibin A as well. Several type I I activin receptors have been identified and bind to different activins with different affinities.
![通用.jpg 通用.jpg](/SupplyImg/2024-04-17/6384897175796240564029794.jpg)