Tissue factor/TF蛋白-ACROBiosystems百普赛斯

Coagulation Factor III产品信息

英文名称：Tissue factor

中文名称：组织因子

靶点别称：Coagulation Factor III,Tissue Factor,TF,F3,CD142

物种：Human/Mouse/Cynomolgus

属性：Protein

标记：Unconjugated

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>90% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

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Coagulation Factor III分子背景

全长组织因子（TF）是因子（F）VII/FVIIa的跨膜受体和辅因子。除了全长TF外，还可以产生另一种剪接（as）形式的TF，它缺乏跨膜结构域，并从细胞中释放出来。与TF相比，asTF的促凝血活性较低，因为它缺乏跨膜结构域。组织因子由血管周围的细胞（如外膜成纤维细胞）和体表（如上皮细胞）表达，在止血中起着关键作用。TF也会导致各种形式的血栓形成。许多癌症，特别是腺癌，表达高水平的TF。在许多类型的癌症中，包括乳腺癌、前列腺癌、结直肠癌和胰腺癌，高水平的肿瘤TF表达与预后不良有关。