癸氧喹酯

Chemistry - A coccidiostat, decoquinate occurs as a cream to buff-colored fine amorphous pow­der having a slight odor. It is insoluble in water.

Storage/Stability/Compatibility - Decoquinate is reportedly incompatible with strong bases or oxidizing material. Follow label storage directions; store in a cool, dry place. Deccox® is labeled as being compatible (and cleared for use) with bacitracin zinc (with or without roxarsone), chlortetracycline, and lincomycin.

Pharmacology - Decoquinate is 4-hydroxy quinolone agent that has anticoccidial activity. Decoquinate act on the sporozoite stage of the life cycle. The sporozoite apparently can still penetrate the host intestinal cell, but further development is prevented. The mechanism of action for decoquinate is to disrupt electron transport in the mitochondrial cytochrome system of coccidia.

Uses/Indications - Decoquinate is labelled for use in cattle for the prevention of coccidiosis in either ruminating or non-ruminating calves, cattle or young goats caused by the species E. chris­tenseni or E. ninakohlyakimoviae . It is used for prevention of coccidiosis in broilers caused by E. tenella, E. necatrix, E. acervulina, E. mivati, E. maxima or E. burnetti.