整合素 α1β1 抑制剂多肽Obtustatin/Obtustatin

Product Name：Obtustatin

CAS No.：N/A

Synonyms：整合素 α1β1 抑制剂多肽Obtustatin

Catalog No.：217P588

Brand：HongTide（上海鸿肽生物）

Description：Obtustatin是一种有效的整合素 α1β1 抑制剂多肽，是由41个氨基酸组成的环状多肽，含有四对二硫键，Obtustatin对 α1β1 与 IV 型胶原结合的 IC50 为 0.8 nM。Obtustatin 在鸡绒毛尿囊模型中抑制 FGF2 刺激的血管生成。 Obtustatin在 Lewis 肺癌的协同小鼠模型中显示出抗肿瘤功效。 Obtustatin 可阻止裸鼠中人黑色素瘤的生长。

Obustatin is an effective integrin α one β 1 inhibitor peptide is a cyclic peptide composed of 41 amino acids, containing four pairs of disulfide bonds, and Obustatin α one β The IC50 bound to type IV collagen is 0.8 nM. Obustatin inhibits angiogenesis stimulated by FGF2 in a chicken chorioallantoic model. Obustatin demonstrated anti-tumor efficacy in a synergistic mouse model of Lewis lung cancer. Obustatin can prevent the growth of human melanoma in nude mice.

Purity (HPLC) ≥98.0%

Single impurity≤2%

Peptide content≥75.0%

Amino Acid Composition≤±15%

Bacterial Endotoxins≤50EU/mg

Solubility：H₂O/DMSO

Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.

Storage:Cool dry place( Store at -20°C, away from the light)

Remark:For Research Use Only. Not for human use.

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