TRAILR2重组蛋白-ACROBiosystems百普赛斯

TRAILR2产品信息

英文名称：Tumor necrosis factor receptor superfamily member 10B

中文名称：肿瘤坏死因子受体超家族成员10B

靶点别称：TNFRSF10B,TRAILR2,TRAIL-R2,CD262,DR5,KILLER,TRICK2,ZTNFR9,TRICKB

物种：Human / Mouse / Cynomolgus

标签：His Tag & Avi Tag / His Tag / Fc Tag

属性：Protein

标记：Biotin-labeled / Unconjugated

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>95% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

1. -20°C to -70°C for 12 months in lyophilized state;

2. -70°C for 3 months under sterile conditions after reconstitution.

TRAILR2分子背景

肿瘤坏死因子受体超家族成员10B（TNFRSF10B）也称为TNF相关凋亡诱导配体受体2（TRAILR2）、死亡受体5（DR5）、CD262、KILLER，是TNF受体超家族的成员，含有细胞内死亡结构域。TNFRSF10B/DR-5在成人和胎儿组织中广泛表达；在肿瘤细胞系中高度表达。TRAILR2/CD262/DR5是细胞毒性配体TNFSF10/TRAIL的受体。TRAIL-R2/TNFRSF10B的衔接分子FADD（一种含有死亡结构域的衔接蛋白）将胱天蛋白酶-8募集到活化的受体上。由此产生的死亡诱导信号复合物（DISC）进行胱天蛋白酶-8蛋白水解激活，启动随后介导凋亡的胱天蛋白酶（天冬氨酸特异性半胱氨酸蛋白酶）级联反应。CD262/DR5促进NF-kappa-B的激活。DR5对ER应激诱导的细胞凋亡至关重要，并受p53/TP53的调节。