α突触核蛋白（α-synuclein）-ACROBiosystems百普赛斯

Alpha-Synuclein产品信息

英文名称：Alpha-synuclein

中文名称：α-突触核蛋白

靶点别称：NACP,PARK1,PARK4

物种：Human / Mouse / Cynomolgus

属性：Protein / Cell

标记：Biotin-labeled / Unconjugated

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>95% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in 100 mM NaAC, pH7.0 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

1. -20°C to -70°C for 12 months in lyophilized state;

2. -70°C for 3 months under sterile conditions after reconstitution.

Alpha-Synuclein分子背景

α-突触核蛋白是一种神经元蛋白，在突触活动中起着多种作用，如调节突触小泡的运输和随后的神经递质释放。它在多聚体膜结合状态下也充当分子伴侣，协助突触前质膜上称为SNARE（可溶性NSF附着蛋白受体）的突触融合成分与半胱氨酸串蛋白α/DNAJC5结合折叠。α-突触核蛋白的异常与帕金森病（PD）的发病机制有关。α-突触核蛋白存在于路易体内，这是帕金森病的神经病理学标志，该蛋白及其聚集与最终导致神经退行性变的神经毒性途径广泛相关。

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