玻连蛋白Vitronectin，ACROBiosystems百普赛斯

Vitronectin产品信息

英文名称：Vitronectin

中文名称：玻连蛋白

靶点别称：VTN,V75,VN,Vitronectin,S-protein,Serum-spreading factor

物种：Human

标签：Tag Free

属性：Protein

标记：Unconjugated

表达区间及表达系统（Source）

Human Vitronectin Protein, Tag Free (VIN-H52H3) is expressed from human 293 cells (HEK293). It contains AA Asp 20 - Leu 478 (Accession # P04004 ).

Predicted N-terminus: Asp 20

蛋白结构（Molecular Characterization）

This protein carries no "tag".

The protein has a calculated MW of 52.3 kDa. The protein migrates as 55-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 0.1 EU per μg by the LAL method.

纯度（Purity）

>90% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

1. -20°C to -70°C for 12 months in lyophilized state;

2. -70°C for 3 months under sterile conditions after reconstitution.

Vitronectin分子背景

Vitronectin也被称为S蛋白、VN、VTN、V75。Vitronectin是一种多功能糖蛋白，参与凝血、抑制膜攻击复合物（MAC）的形成、细胞粘附和迁移、伤口愈合和组织重塑。玻连蛋白的主要细胞来源是肝细胞。特异性抗血清或基因缺失阻断Hic（肺炎球菌表面蛋白C（PspC）家族的成员）分别显著降低了肺炎球菌与可溶性和固定化玻连蛋白以及因子H的结合。此外，Vitronectin与糖胺聚糖和蛋白多糖相互作用。被整合素家族的某些成员识别，并作为细胞与底物的粘附分子。末端溶细胞补体途径膜损伤作用的抑制剂。