HMGB1重组蛋白，ACROBiosystems百普赛斯

HMGB1产品信息

英文名称：High Mobility Group Protein B1

中文名称：高迁移率族蛋白B1

靶点别称：HMGB1,HMG1,HMG3,SBP-1

物种：Human / Mouse

标签：His Tag / Mouse IgG Fc Tag

属性：Protein

标记：Unconjugated

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>90% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

1. -20°C to -70°C for 12 months in lyophilized state;

2. -70°C for 3 months under sterile conditions after reconstitution.

HMGB1分子背景

高迁移率族蛋白B1（HMGB1）也称为高迁移率群蛋白1（HMG-1）和两性霉素，是由HMGB1、HMGB2和HMGB3三个成员组成的HMGB家族的成员。HMGB1是一种非组蛋白结构的染色体蛋白，普遍存在于所有脊椎动物的细胞核中，与双链DNA结合时没有序列特异性。炎症和损伤的机制与TLR4结合，TLR4介导HMGB1依赖性激活巨噬细胞细胞因子的释放。这使HMGB1处于无菌和感染性炎症反应的交叉点。HMGB1已被研究作为DNA疫苗佐剂和癌症治疗的靶点。