Annexin A5重组蛋白，ACROBiosystems百普赛斯

Annexin A5产品信息

物种：Human

标签：Tag Free / His Tag & Avi Tag / His Tag

属性：Protein

标记：Biotin-labeled / Unconjugated

分子别名（Synonym）

ANXA5,ANX5,ENX2,PP4,Annexin V,Annexin A5

内毒素（Endotoxin）

Less than 0.1 EU per μg by the LAL method.

无菌（Sterility）

The sterility testing was performed by membrane filtration method.

支原体（Mycoplasma）

Negative.

纯度（Purity）

>90% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

1. -20°C to -70°C for 12 months in lyophilized state;

2. -70°C for 3 months under sterile conditions after reconstitution.

Annexin A5分子背景

Annexin A5是一种磷脂结合蛋白，在钙的存在下以高亲和力和选择性结合PS。PS主要位于面向细胞质的膜小叶中。然而，最近的研究结果表明，每种细胞类型都有在其细胞表面暴露PS的分子机制。这种机制在细胞凋亡过程中被激活。一旦PS暴露在细胞表面，它就会表现出促凝和促炎活性。Annexin A5会与PS暴露的凋亡细胞结合，并能抑制垂死细胞的促凝和促炎活性。Annexin A5也被确定为凝血级联中的一种抗凝蛋白，作为凝血酶原激活的抑制剂。Annexin A5抗体的存在与系统性红斑狼疮（SLE）、复发性自然流产和系统性硬化症（SSc）有关。